Healthy Aging from the Inside Out

September 4, 2020

A recent study suggests calcium alpha-ketoglutarate could positively affect aging, with increases in lifespan, a reduction in frailty, and increase in healthspan.

Aging is inevitable, but what if we could slow the process and the make the side effects of getting older a little easier?

A recent study conducted by the Buck Institute for Research on Aging found that calcium alpha-ketoglutarate (Ca-AKG), a stable form of alpha-ketoglutarate (AKG), administered to mice beginning at 18 months of age (middle age) showed a 12% increase in lifespan, a 46% reduction in frailty, and a 41% increase in healthspan.

“What is important about the study is the fact that adding calcium alpha-ketoglutarate to the diet not only delayed aging, it also compressed morbidity,” says Azar Asadi Shahmirzadi, PhD, PharmD, and lead study researcher. “This study suggests that aging and associated comorbidities are not inevitable and may likely be managed.”

These findings indicate that Ca-AKG on humans could possibly increase wellness while reducing age-related illness.

“… this could meaningfully reduce the period of time spent suffering from age-related conditions, increase the period of healthy living, and dramatically reduce the cost of providing healthcare to an aging population,” says Tom Weldon, founder and CEO of Ponce De Leon Health, Inc.

“Although the study was conducted on animals, humans share a number of major molecular aging pathways with mice and experience many of the same challenges to health associated with old age,” continues trial’s senior researcher, Brian Kennedy, PhD.