Partner Content

Shino Bay Aguilera, DO (Fort Lauderdale, FL), Monica Bonakdar, MD (Newport Beach, CA), Angela Bowers, MD (Southlake, TX), Vivian Bucay, MD (San Antonio, TX), Anne Chapas, MD N(ew York, NY), Gregory Chernoff, MD (Indianapolis, IN), Suneel Chilukuri, MD (Houston, TX), Sue Ellen Cox, MD (Chapel Hill, NC), Natalie M. Curcio, MD (Nashville, TN), Diane Duncan, MD (Fort Collins, CO), Stephen Friedman, MD (Malibu, CA), Melda Isaac, MD (Washington, DC), Gregory Keller, MD (Santa Barbara, CA), Pamela Keller, RN (Santa Barbara, CA), Steven Swengel, MD (Los Gatos, CA), Amy Forman Taub, MD (Chicago, IL), Jessica Weiser, MD (New York, NY).

If you ever mused aloud, ‘I wish I could slather my entire body with DefenAge,’ then the new 10 Luxe Hand & Body Cream answers your call. According to key opinion leaders in aesthetic medicine, the new 

 delivers much more than a product that simply feels soft to the touch.

“The future of Aesthetics is regenerative medicine, and this includes new advances in skincare products. DefenAge’s new body cream reprograms your dormant cells to create new skin cells from head to toe. My skin is now mainly comprised of young cells, and it shows,” commented dermatologist Shino Bay Aguilera, DO, of Fort Lauderdale, Florida.

ESSENTIAL SKINCARE IN DERMATOLOGY PRACTICE

Medical Director of the largest Southlake, Texas, dermatology practice, Angela Bowers, MD, is one of the first physicians in the US to test the new 

 and is enthusiastic to start offering it to her patients as soon as the product becomes publicly available. 

“We consider DefenAge an essential skincare product. The new 

 is a wonderful addition that we will all be using. It has a great texture, is an excellent moisturizer, and improves the look of both the sun damage and aging part of our skin,” Dr. Bowers commented.

“DefenAge has been working on developing, improving, and refining defensin skincare technology over the last 7 years. I have had the pleasure of not only being a happy consumer of all their products, but also a board-certified cosmetic dermatologist who has seen the entire product line grow with impressive product after product with cutting-edge technologies that I have had the pleasure of sharing with many patients who have benefited from this exclusive skincare,” said dermatologist and dermatologic surgeon Natalie M. Curcio, MD, MPH, who practices in Nashville, Tennessee. “From the face to the eyes to the neck and décolleté, DefenAge has changed the way we view the possibilities for topical skincare, and similarly, the way in which we see ourselves every day in the mirror. The 

 is a demanded addition to the DefenAge skincare portfolio. The time has arrived to ‘turn the clock back’ with DefenAge on aging hand and body skin just as we have been doing already with other DefenAge products on our faces, eyes, and neck.”

Director of UnionDerm in New York City, dermatologist Anne Chapas, MD, explains: “My patients are looking for effective anti-aging solutions for the face and the body. With the new DefenAge body cream, they have an option that goes beyond typical moisturizers to improve the appearance of their skin and help to reverse the aging process.”

“any patient who uses DefenAge sees an improvement in the tone, quality, and clarity of their skin”

Aesthetic physician, Monica Bonakdar, MD, of Newport Beach, California, echoes the sentiment that the new body cream by DefenAge closes a gap in skincare.

“DefenAge’s Body Cream meets the long-awaited need for a body cream that is both an effective anti-aging product as well a luxurious, feel-good product. The addition of this cream to the curated products aesthetic practices carry inhouse is a must,” Dr. Bonakdar said.

Since the initial launch of DefenAge in 2015, multiple reports from practicing aesthetic physicians have indicated defensin-containing products efficiently address crepey skin and improve visible skin firmness. Doctors report an initial improvement within a few days and long-lasting results after the completion of a 6-week regimen.

, my dry skin instantly looks and feels better; it is perfect for crepey skin, especially in a dry climate,” said plastic and reconstructive surgeon Diane Duncan, MD, of Fort Collins, Colorado. “There is a lack of effective treatment options for aging skin on the arms, legs, and torso. So, the introduction of a scientifically-backed, effective regenerative body cream is a welcome addition to the DefenAge range that I already recommend to my patients.”

Dermatologist Steven Swengel, MD, of Los Gatos, California, agreed that the 

 will be a great option for larger body areas, including crepey skin.

“So many patients are complaining about creping changes to their arms and legs, and while previously I suggested they use a pump of DefenAge 

 mixed with their favorite body lotion, the new body cream will encourage the use of body-specific products instead of trying to fit facial products on body areas,” Dr. Swengel said.

“moisturizes, hydrates, and immediately, the skin feels firmer and plumper”

Dermatologist and dermatologic surgeon Suneel Chilukuri, MD, of Houston, Texas, concurs that having a science-backed topical to address crepey skin is a win for both patients and aesthetic doctors. He shared the results of an internal pilot study of the body cream in his clinic.

“Our patients have been waiting for a topical solution to address crepey skin that actually does more than a store-bought moisturizer,” Dr. Chilukuri said. “I finally have a scientifically proven option with DefenAge’s 

. In our split inner arm and lower thigh testing, patients have seen a difference on the treated side within 2 weeks that continues to improve over the next 12 weeks.”

Notorious trouble spots like elbows and knees have always been a focus of aesthetic practitioners. Now, the new body cream brings a target-specific product to improve the look, restore softness, and visibly revive the smooth texture of these challenging areas of the body.

“The defensin-based technology can actually reverse the appearance of aging skin, so much so that areas that might otherwise be covered, such as the upper arms, elbows, and knees, can now be exposed again,” Dr. Duncan commented.

Partner at Keller Plastic Surgery Pamela Keller, RN, of Santa Barbara, California, shares her experience with the 

: “Being almost 60, with gardening as a hobby, kneeling and using my gardening tools caused my knees and arms to become rough and almost ‘calloused.’ I saw a dramatic improvement in my crepey skin and roughness just a few days after I started using DefenAge’s new body cream. There is no doubt that I will recommend my patients to use the 

 on their elbows and knees, who are already asking how I got such an improvement.”

Since the publication of a multi-center, double-blind clinical trial on defensins,

 dermatologists widely recommend DefenAge to their patients as a safe retinol alternative delivering similar results without irritation, inflammation, or increased sun-sensitivity. 

Dermatologist Stephen Friedman, MD, of Malibu, California, conducted a dorsal arm bilateral comparison of the 

 to an advanced retinol-containing body lotion, additionally supplemented with hydrating and barrier repair ingredients. Dr. Friedman concluded that DefenAge’s new body cream produced comparable clinical benefits to the retinol lotion.

“In the brief open clinical trial, there is no perceptible difference in the appearance of the right and left dorsal arms. The degree of hydration, texture, and color were identical,” Dr. Friedman said.

BIG FUTURE IN COMBINATION WITH BODY TREATMENTS

“The non-surgical body contouring industry is increasing significantly. I will recommend using the 

with defensin technology to my patients to improve the quality of the skin long after we reduce the patient’s fat and tone their muscle. Defensins help us to ‘ice the cake’ on the patient’s overall quality of the result. It has been a welcome addition to my armamentarium of body treatments. It also fits into our new ‘biostimulatory’ story for skin improvement,” shared facial plastic and reconstructive surgeon Gregory Chernoff, MD, of Indianapolis, Indiana. “I have been using defensin technology in my offices since the inception of DefenAge. My patients made me a believer, as without exception any patient who uses DefenAge sees an improvement in the tone, quality, and clarity of their skin.”

A long-time DefenAge enthusiast, Dr. Duncan published a study in 

Facial Plastic Surgery Clinics of North America

in 2018 examining the combination of DefenAge defensin serum and microneedling to enhance cosmetic outcomes on the face and body.2 She reported: “Use of a defensin-based serum (DefenAge) after microneedling can create a remarkable improvement in skin quality” on the arm with a single treatment, including addressing visible signs of solar elastosis, wrinkling, and poor skin tone.” The improvement stays at least one month after treatment.

 with BBL Hero (Sciton) treatments. The device by Sciton can reduce pigment, sun damage, crepiness, and mild skin laxity in a manner similar to using DefenAge post microneedling,” Dr. Duncan said. “The thermal effect of the device on skin will be amplified by the post-treatment application of the DefenAge body cream. I plan to instruct patients to use the 

 two to three times a day following four weekly treatments with the BBL.”

Dr. Chilukuri plans to use the new body cream to optimize the skin prior to light-based or radiofrequency treatment: “My patients will apply DefenAge for a minimum of two weeks to make sure the appropriate cellular mediators are in place to enhance short and long term results.”

Assistant Clinical Professor of Dermatology at Columbia University Jessica Weiser, MD, who practices at SoHo New York, commented: “The new DefenAge 

 is a very exciting addition to this incredibly luxurious and effective line of skincare products. Like the face and neck products, the body cream contains the coveted defensins in addition to a strong lineup of active ingredients to target stubborn crepey skin on the body, while enriching the skin barrier and providing excellent emollition.”

“When used alongside radiofrequency microneedling, such as Cutera Secret RF, which is one of my go-to procedures for firming and resurfacing of arms, legs, abdomen, and more, the DefenAge body cream ingredients add anti-aging benefits while simultaneously ameliorating the healing process. I cannot wait to offer this innovative product to my patients,” Dr. Weiser added.

ACTS FAST, PENETRATES WELL, HAS ELEGANT TEXTURE

Dermatologist Melda Isaac, MD, of Washington, DC, shared she is impressed with the immediate effects of the body cream: “I am thrilled to introduce the 

 to my patients. The feeling is elegant. The smell is pleasant and clean. It absorbs fairly quickly and is not at all sticky or tacky. It moisturizes, hydrates, and immediately, the skin feels firmer and plumper.”

“The texture is perfect, thick enough without feeling too heavy. Application is smooth without feeling greasy,” adds Dr. Duncan.

An enhanced consumer experience with the new 

 is also highlighted by a Principal Investigator of the fundamental clinical research on defensins, dermatologist Amy Forman Taub, MD, of Lincolnshire, Illinois: “I love it. It is rich, and penetrates well, and I love that the pump gives you a lot in one draw.”

“Most anti-aging body creams just make a simple lotion and add their hero ingredient. By creating a body cream with barrier repair and antiflammatory ingredients in addition to defensins, the 

 gives me confidence I am recommending the very best anti-aging body cream to my patients due to its robust multi-function,” says Dr. Taub.

Drawing from seven years of clinical data utilizing defensins in cutting-edge skin care, DefenAge has spent more than two years refining the final formulation of 

. The strategy behind the formulation is based on 4 pillars addressing all key areas of the care of body skin:

Pillar 4. DefenAge’s hero, proven, high-performing blend of ingredients

Today’s hand and body cream is a result of at least 6 product revisions based on doctor’s feedback.

As a clinical researcher and multi-year user of DefenAge, dermatologist Vivian Bucay, MD, of San Antonio, Texas, is keenly aware of defensin technology. She also reviewed the strategy behind the formulation of the 

“As a dermatologist who strives to care for both the medical and cosmetic concerns of my patients, good skincare is not limited to the face and neck. It includes the entire body. An ingredient and evidence-based approach to skincare makes sense to me and allows me to explain the benefits of a particular product to my patients. Several years ago, I became a fan of DefenAge, an innovative skincare line that leverages defensins, molecules that have the ability to stimulate a subset of dormant stem cells to create a more youthful epidermis,” says Dr. Bucay.

She cites a multi-center, double-blinded, vehicle-controlled clinical trial published in the 

1illustrating histologic confirmation of the benefits of a 12-week, twice daily application of an alpha and beta defensin-containing facial barrier cream and serum.

“A few months ago, I had the opportunity to try DefenAge’s 

, which feels very lightweight and absorbs quickly while still delivering long-lasting hydration. What really appeals to me are the 4 pillars that are the foundation of the formulation: anti-aging on a global scale provided by defensins; hydration and barrier repair by 

 ferment; soothing and calming by sea whip and panthenol; and a hero blend of ingredients that are compatible with defensins, including niacinamide (aka multitasking vitamin B3 that plays a key role in skin immunology, barrier function, and pigmentation, to name a few) and squalane,” Dr. Bucay said.

Facial plastic surgeon and Clinical Professor at UCLA Gregory Keller, MD, FACS, of Los Angeles, California is specific when he talks about why he thinks DefenAge’s new 

 will be a game-changer for his patients: “The unique feature of DefenAge is its famous and proven defensin molecules, which studies have shown have an ability to message a targeted regenerative response to the skin. The new body cream is the first-ever body skincare product that contains defensins.”

Investigators have examined the safety and efficacy of defensin-molecules and DefenAge’s formulas in 15 clinical studies, including the fundamental research published in 2018 in the 

 The authors concluded that a defensin-containing cosmetic skincare regimen promotes a healthy new epidermis and “globally improves the visual appearance and structure of aging skin without irritation, dryness, or inflammation.”

ORCHESTRATING THE IDEAL COMBINATION OF INGREDIENTS PAIRED WITH DEFENSINS

Defensins are not the only reason doctors so enthusiastically embrace the 

. The new body cream is supplemented with advanced high-performing skincare ingredients and additional technologies that are proven to work extremely well with defensin-molecules, amplifying the defensin’s effects. DefenAge calls it their “hero blend.”

Dermatologist Sue Ellen Cox, MD, of Chapel Hill, North Carolina, comments: “The new DefenAge body cream addresses an unmet need in the beauty industry. It has the same evidence-based science as the legacy products. It takes advantage of anti-aging ingredients paired with the defensin-molecules to revive aging skin.”

One of the champions of DefenAge’s hero blend is niacinamide, which soothes and revives the skin’s natural moisture barrier, renews the feeling of skin firmness and elasticity, and brightens overall skin tone. DefenAge’s scientists say the success of niacinamide in DefenAge is due to an entirely different mechanism of action between niacinamide and defensins, meaning they complement each other, delivering multiplying results on the skin. DefenAge’s scientists have used a combination of niacinamide and defensins from the formula’s inception, starting with the 

Squalane is another component of the hero blend, although relatively new for DefenAge. Squalane adds a direct hydration component to the skin and can be found in the 

“I only recommend skincare products that are backed by science. All DefenAge products, including the new body cream, contain ingredients that are clinically proven to visibly rejuvenate, hydrate, and brighten skin,” added Dr. Isaac.

In addition to defensins and its hero blend, the DefenAge 

“First, it is the anti-inflammatory pillar. The body cream contains a top-level concentration range of an ingredient called sea whip, a powerful natural ingredient obtained from gorgonian coral grown in the Caribbean. It helps soothe skin redness and irritation, while softening skin,” Dr. Curcio said.

Sea whip’s benefits were proven as early as in as early as 1986 in the study, “

The pseudopterosins: anti-inflammatory and

analgesic natural products from the sea whip Pseudopterogorgia elisabethae

Proceedings of the National Academy of Sciences of the United States of America

The enhanced soothing effect is reported by Dr. Keller (

“I’m a surgeon and wear sterile gloves for hours. My hands and fingers often become irritated. Use of the new 

 has relieved the irritation and left my hands soft and smooth,” Dr. Keller said.

According to DefenAge’s scientists, the final defining feature of the new formulation is that it boosts the skin’s barrier by enhancing the skin’s natural functions via an advanced hydration complex.

 root extract not only provides a barrier balancing effect, similar to ceramides by promoting the skin’s natural lipids, but also contributes to skin hydration by increasing levels of natural moisturizing factors (aka, NMFs).

 ferment, stimulates the skin’s natural hyaluronic acid, laminin, and elastin.

“Overall, both ingredients balance the epidermal barrier, moisturize, smooth the skin’s texture, improve cosmetic elasticity, and minimize visible signs of premature aging,” Dr. Curcio comments.

“After reviewing the science,” she says, “it is easy to understand why DefenAge’s new hand and body cream feels great when applied to the skin, relieves dryness and itching (even in dry, sensitive skin like mine), and enables moisturization that lasts and lasts while contributing to anti-aging and improving the look and feel of the skin itself. It is with great enthusiasm that I welcome the 

. For many of us… it has been a long-awaited arrival!”

Taub A, Bucay V, Keller G, Williams J, Mehregan D. Multi-Center, Double-Blind, Vehicle-Controlled Clinical Trial of an Alpha and Beta Defensin-Containing Anti-Aging Skin Care Regimen With Clinical, Histopathologic, Immunohistochemical, Photographic, and Ultrasound Evaluation. J Drugs Dermatol. 2018 Apr 1;17(4):426-441. [

Duncan DI. Microneedling with Biologicals: Advantages and Limitations. Facial Plast Surg Clin North Am. 2018 Nov;26(4):447-454. [

Look SA, Fenical W, Jacobs RS, Clardy J. The pseudopterosins: anti-inflammatory and analgesic natural products from the sea whip Pseudopterogorgia elisabethae. Proc Natl Acad Sci U S A. 1986 Sep;83(17):6238-40. [

Articles

DefenAge unveils the first-ever body cream containing defensins.

Backed by Science, New Body Cream Redefines Expectations of Aesthetic Medical Professionals

 Perfect Intense Liquid from a well-respected aesthetic representative who was aware of my interest in chemical peels. I have performed many TCA based treatments in my clinic and is quite familiar with that product. That combination of 33% TCA with hydrogen peroxide and Kojic acid used is a bio-revitalization agent seems new and exciting. This made sense as each individual component has a significant merit but this particular combination was new to the aesthetic market.

I had my doubts that this product would offer significant benefit over already existing TCA treatment protocol. Would the ingredients work well together in a synergistic fashion? What would the outcome be for my clients as the product claimed to be “one size fits all”? Would there be a downtime for my patients? Just a few burning questions that popped into my head before agreeing to attend the training session. I have all too often seen and tried new products within the industry with good marketing and poor limited effects which prove to be nothing more than aesthetic fads.

After the first training session with PRX-T

, my skepticism flew out of the window! The immediate results spoke for themselves. The science behind this formulation seemed simple, effective and clever.

This protocol is effective for all Fitzpatrick skin types, can be used year-round and can be combined with other frequently offered procedures such as toxin administration, microneedling, PRP, PDO threads and dermal fillers.

 quickly replaced my standard baseline “peel” as I started using it as a primer before other treatments. Clients would come in requesting PRX-T

 by name, not ever having any kind of aesthetic treatments before. The greatest growth in my first year was from clients booking to have a PRX-T

 session together with their 3-monthly toxin treatments and from there it quickly gained a reputation as a medical grade facial without any actual peeling. Most of my clients are busy executives and cannot afford to have visible downtime. In 2020 more so with the rise in video conferencing and work from home. Hence a quick and effective procedure such as PRX-T

 lead to a high satisfaction level. The easy to follow 3-step application protocol is safe and effective for even the most novel of skins. The profit margins are exceptionally good and PRX-T

 does not require any specialized equipment or devices to perform. All that is required is a steady hand, an applicator and nitrile gloves. It is as easy as that. The application technique remains the same for other areas such as the neck, chest and hands.

 does not cause dreaded post-inflammatory hyperpigmentation and this is thanks to the addition of Kojic acid to the formulation.

Patients experience the instant tightening effects, as well as softening of lines and wrinkles together with an overall brightening and radiance of their complexion. Stretch marks and sunspots on the face, neck, décolleté and hands are also effectively improved by using PRX-T

 is a combination treatment with microneedling for the treatment of depressed scars and hyperpigmentation associated with acne. A course of three sessions, one month apart where at each session, a base layer of PRX-T

 is applied to the whole face, immediately followed by mechanical microneedling. This synergistic protocol provides the multiple benefits such as tightening of the depressed scar, lifting from the base, collagen induction and lightening of the post inflammatory hyperpigmentation. Significant improvements can be seen from the first session in both texture and tone of the skin. This regimen is just as effective as the previous TCA treatment but significantly decreases healing time and posttreatment morbidity.

This protocol is excellent for clients who have large open pores and require skin tightening and sebum control. Moderate sun damage with hyperpigmented were collagen and elastin stimulation is required can also benefit from this treatment. The results are visible, effective and long-lasting leading to high patient satisfaction.

I had become such a dedicated user of PRX-T

 that I did not hesitate to become the UK trainer for the WiQo portfolio of products when approached, of course with PRX-T

 becoming the leading procedure in skin biorevitalisation.

Dr. Zunaid Alli, MBBCh, MBA, HonsBSc, BSc, London (UK)

Dr. Zunaid Alli shares his journey to evidence-based results: PRX-T33/microneedling in combination for pores and scars. 

Evidence-Based Results: Combining PRX-T33/Microneedling 

What is the most important ingredient in your kitchen? A very expensive, exotic herb? A never-heard-before flavour from far away? The latest superfood? Often the decisive factor of success is something we give totally for granted: humble table salt, for instance, is in all preparations: from savoury to sweet, its unobtrusive presence exalts flavour, and you definitely notice when it’s missing. The trick is moderation, and skills mastery.

I’ve been one of the first to use PRX-T33 – a cosmetic for professional use recently launched on the US market – but by now there is an expanding and enthusiastic userbase. It’s a dermal rejuvenator that triggers the skin’s own reparative system leading to a naturalistic and quick rejuvenation. It’s applied topically, with manual technique taught in training sessions during which you can discover the many uses of PRX-T33.

With PRX-T33 you can achieve what many practitioners have always dreamed – even though many maybe didn’t know it: immediate results, perfect for the “lunchtime-break clients”, naturalistic, subtle, noticeable, downtime-free skin improvement which is not restricted to certain times of the year (PRX-T33 can be used even in the summer months provided the patient uses adequate photoprotection). How often have doctors wished there were an effective and safe treatment that does not require a high starting cost and high commitment from the patient? Well here it is!

PRX-T33 is great for new practitioners, since it is an easy application process, but also for advanced ones, because it can be integrated with many other services. Similar to connective tissue massage, the gel is applied with specific pressure that anyone can learn to maximize absorption and get the best outcome. PRX-T33 is very safe for all skin types. It can be used all year long, even during the sunny months as it does not cause photo-sensitivity. There is virtually no downtime and it is safe for all skin types. For these reasons it is a great introductory service for new clients that are nervous about aggressive treatments that have long “down times”. I’ve noticed that men are great candidates as well, because they will look great afterwards, but no one suspects they had an aesthetics service provided to them. PRX-T33 can also be combined with other services such as Microneedling with or without RF, PDO threads and a host of other services. PRX-T33 combined with other services yields results that are superior to each treatment on its own, while increasing revenue per service. The post care products included as part of the PRX-T33 experience are specifically designed to make sure clients use the best home care in between PRX-T33 treatments. Many clients will want to continue home use of these products after their initial cycle is over, so that creates and additional revenue source. The minimum treatment cycle with PRX-T33 is of 4 treatments for the face and body; this typically generates $1000 per cycle - resulting in a high ROI for the practitioner. Most importantly, clients see an immediate improvement in their skin after just one treatment. Having clients get up from the treatment bed and say “wow!” is always rewarding! To me, Wiqo PRX-T33 has proved to be a game changer for my practice in so many ways. It has provided me with an effective skin rejuvenating service that I can offer to my darker Fitzpatrick patients without the associated risks of post-inflammatory skin changes. Prior to having PRX-T33, treating a darker Fitzpatrick skin type generally required several weeks of pre-treatment with Hydroquinone to avoid unwanted pigmentary changes. Now I can start the first treatment the same day as the consultation for almost all my patients. Patient satisfaction rate is high due to the immediate visible results with no required downtime and no photosensitivity. Patients see and feel immediate tightening in the skin following the application of the PRX-T33 and the skin takes on a youthful translucence in color. It is the ideal “Red Carpet” treatment that delivers the efficacy of 33% TCA to the Dermis without ever causing any frosting. This to me is a “game changer” in the Aesthetics industry as Wiqo is providing us with an effective rejuvenation process that does not adversely affect the epidermal barrier. I have been a certified clinical aesthetician and trusted skin care expert with 30 years’ experience in dermatology and the plastic surgery industry and I can, without hesitation say that this is the most advanced skin care treatment I have encountered in my career.

So, what’s the most important ingredient in your practice? Well, your expertise, of course. No one can replace that. Now just think of what you can achieve with PRX-T33.

Wiqo explains how to see familiar ingredients in a whole new way with PRX-T33.

Unlock Your Profit Potential with the Revolutionary PRX Protocol

I had the pleasure of practicing facial plastic surgery in the US over the last 25 years and have seen many tech­niques and treatments come and go. I have seen the boom of chemical peels replaced by a variety of ablative and non-ablative lasers increasing the cost and fre­quently bringing little benefit to our patients. Some of those treatments had some useful nich­es, however most of them were associated with treatment discomfort and a prolonged post-procedure recovery. The results were noticeable, however they were frequently better with more “aggressive” procedures and were associated with greater risks and complications.

What was missing was a procedure that would fill the needs of modern working women (and men) to be safe, quick, effective, long-lasting with min­imal downtime. This procedure was missing until WiQo product PRX-T33 was introduced to the Unit­ed States at the end of last year.

The basic canon of aesthetic medicine was that procedure must be aggressive to be effective. This is something I learned in my residency and was reinforced in my fellowship. This is a belief I held until PRX-PROTOCOL was first integrated into my aesthetic practice. I was first introduced to this product at the International Aesthetic Con­ference by my fellow European colleagues in 2019. My wife had her first application and was amazed by the results. The effects were immediate. Her skin felt firmer, was more translucent with a sense of “glow”. The procedure was quick, no more than 20 minutes. There was no discomfort other than mild itching during the application. There was no downtime and she was able to use her makeup so we could meet our friends for dinner the same day.

Since its introduction, PRX-T33 has taken the US by storm. It is an ideal care protocol for a busy woman, as it does not require prolonged rehabili­tation and has immediate results. With over 2 mil­lion applications performed since the product was put to market in 2012, the safety and efficacy of this protocol - currently used in over 40 countries - is unmatched.

PRX-T33 contains 33% trichloroacetic acid (TCA) - which is reflected in its name - as well as hydrogen peroxide, the real key ingredient in an “effortless transformation” revolution. The symbi­otic relationship between those components leads to beautification: this is the stroke of genius which led to the international patent of PRX-T33, granted in 2006.

PRX-T33 Perfect Intense Liquid is easy to use in the practice setting, can be applied by skin thera­pists under physician supervision and has multiple immediate and long-lasting benefits to our clients. It is non-photosensitizing and can be used year-round, safe on all Fitzpatrick skin types and has essentially no need for downtime. As stated be­fore, results are visible and palpable after the ini­tial procedure and are stable for 6-8 months after a series of 4 to 5 weekly sessions.

For those who are scientifically curious, I can tell you that the mechanism of action is based on a controlled stimulation of the skin thanks to the bal­anced action of the ingredients on the skin. This allows to improve the quality and the skin texture without the side effects commonly associated with peels. There is a lot of science behind PRX-T33 pro­tocol and I invite you to reach out and take part in the extensive training provided.

Other than obvious patient benefit, there is also a significant benefit to an aesthetic practice. It is a “low risk, high benefit” office procedure that can be performed under physician’s supervision in a medical spa setting by a licensed aestheti­cian. WiQo.US will train and certify your staff in product use and a proper care protocol including step-by-step recommendations. A low initial cost and a high patient retention is ideal for a physician owned medical spa.

All products available through WiQo line have been thoroughly researched and are used exten­sively and nearly exclusively in our facility. PRX PROTOCOL is popular with both men and wom­en, has few limitations and is safe for all age and skin type patients. The company recommends the use of WiQo Moisturizing Face Cream for Dry Skin to restore the hydro-lipidic film immediate­ly after the procedure, and then at home to mini­mize post-care exfoliation. WiQo Facial Smoothing Fluid should also be used to lower the skin pH and create the ideal conditions to prolong the effects of the in-office application.

I have introduced PRX-PROTOCOL in Octo­ber 2019 and it has currently been used for care of face and chest, hands, acne scars and stretch marks and the results have been excellent! The product is well received by our patients and staff. Follow-up procedures are scheduled at the time of departure and the home care protocol is well followed by nearly everyone. Please be aware that advanced applications with PRX-T33 include Mi­croneedling and PDO threads. The company goes to great lengths to provide webinars for addition­al training and certification, and US based staff is available if requested for additional training and to answer whatever questions you may have. I found the manufacturing company GPQ srl to be both responsive and responsible in providing additional information and training.

I was so impressed with this product I be­came a US based Medical Director for GPQ srl. I am proud to be part of the WiQo team and to in­troduce “effortless transformation” care proto­col to my US colleagues.

Click the below image for the PDF of this article:

Since its introduction, WiQo PRX-T33 has taken the US by storm. An ideal care protocol for busy women, it does not require prolonged rehabilitation and has immediate results.

“Effortless transformation” PRX-T33 revolution in aesthetic industry in the US

The most successful doctors in aesthetics apply their knowl­edge and skill to comprehensive patient skin management. Of course, your patients show up for toxin and filler, but while you can temporarily erase their wrinkles with a syringe, it takes more to restore youthful glow and vitality to the skin. Advances in regenerative medicine have yielded a new tool to help achieve those results.

Mesenchymal bone marrow stem cells from a young adult donor are cul­tured in the laboratory to produce precisely the correct balance of cytokines and growth factors for skin healing with minimal inflammation. These biosig­nals, when topically applied, are able to restore the phenotype of young adult skin to a patient of any age.

Formulated into rational products for office-based aesthetics treat­ments and daily home use, this technology is available under the name AnteAGE MD®.

Research has unequivocally shown that chronic inflammation is the catalyst for visible signs of aging in the human body. The hallmark of AnteAGE MD® products are anti-inflammatory ingredients intentionally formulated to give you lasting results, at the cellular level. Conditioned media of the bone marrow stem cell has been shown in a controlled study to accelerate wound healing at twice the efficacy compared to fibroblast cell media.

Cellese together with sister company XOStem are pushing the envelope of regenerative medicine and the promising new field of Exosome therapies.

Exosomes are nanoparticulate extracellular vesicles that aggregate and export paracrine biosignals, nucleic acid modulators of phenotypic expression such as mRNA’s and miRNA’s.

Exosomes are able to diffuse through tissues, seek out target cells, alter local immune functions, and effect changes to skin through epigenetic modulation.

The scientists at XOStem are culturing, classifying, concentrating, and preserving exo­somes to address aesthetic treatment modalities for aging skin and hair loss.

Interested in being a trial site for exosome research in aesthetics? Email 

Patients want something that gives them results they can see quickly without getting convoluted in too many steps. AnteAGE MD® has solved for both. The body’s natural ability to heal and repair itself is the foundational premise of the 2-part Serum and Ac­celerator System. Precisely formulating cultured growth factors with 18 active ingredi­ents, we offer a solution that is easy, safe and effective.

Bone marrow stem cell media and recombinant growth factors combine with classical ingredients that re­pair and improve the signs of aging. In just two steps, flood the skin with regenerative growth factors, vita­min C, vitamin E, hyaluronic acid, bakuchiol (a non-irritating retinol alternative) peptides and antioxidants.

The results include an increase in collagen volume, reduced pore size, an even skin tone, reduction in fine lines and wrinkles and an overall luminous glow that your patients will notice within days.

AnteAGE MD® offers specialized treatment adjuvants to maximize results and minimize downtime. Combining modalities with anti-inflammatory growth factor tools promote healing unlike any other topically applied skin product in the post-procedural scenario.

AnteAGE® restores the skin’s ability to respond to damage and repeat­ed stresses at a level that would be typical of the same person at a much younger age.

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Advances in regenerative medicine yield a new tool to help achieve a youthful glow and vitality to the skin.

Healing Power from Bone Marrow Stem Cells

Today we are a leader in advanced wound care, dental, cosmetic and sports medicine with significant scientific, clinical, operational and commercialization expertise. We aim to contribute to human welfare by application of regenerative medicine in the research, education, distribution and sale of amniotic fluid products that alleviate pain, restore health, restore beauty and extend life. Russell Health is devoted to advancing access and quality care in the area of regenerative medicine to help people suffering from a variety of inflammatory and degenerative conditions. Our credo stems from a belief that “consumers, employees and the community are all equally important.” This statement shows that we are passionate about inclusivity and treating everyone with absolute respect and care.

Stem Cell Recruitment (SCR) Facial™ combines DermaFlo™ and our patent-pending SCR Facial™ Procedure Guide that utilizes a minimally invasive technique. DermaFlo™ is an acellular, chorion-free, pure amniotic fluid product. Amniotic fluid surrounds a baby during pregnancy and has evolved over the mellenia to create the ideal environment for fetal development. This complex fluid is a rich source of nutrients, cytokines and growth factors that manage cellular activity. Russell Health’s tissue bank partner receives amniotic fluid from full-term C-section mothers who agree to donate their amniotic fluid to help others. All donors comply with our tissue bank’s extensive screening policy to ensure the fluid is safe for patient use. Patients have reported a dramatic improvement the appearance of aging, damaged, and post-procedure skin.

The biological components in amniotic fluid help to stimulate collagen production, healthy circulation, antioxidant activity and cellular renewal. Physicians have also reported that this ground-breaking therapy helps to diminish the appearance of post acne scarring and soothe skin traumas. This pure amniotic fluid will not clog pores, leave a greasy feel or irritate sensitive skin.

Stem Cell Recruitment Therapy™ Treatment Areas

“Fountain of Youth” in Amniotic Fluid

The Growth Differentiation Factor 11 (GDF11) in amniotic fluid is being referred to as the “Fountain of Youth” protein by researchers at Harvard. A recent study showed that a protein called GDF11 helps explain why young blood can rejuvenate several tissues, such as dermal tissues.

Improved coloration of skin (skin pigmentation) and definition of jawline.

Diminish appearance of post acne scarring and telangiectasias.

Reduced skin lines around eyes and upper lip.

The Stem Cell Recruitment (SCR) Facial™ follows our patent-pending SCR Facial™ procedure that micro needles amniotic fluid into the epidermal layer of the skin on the face and neck. The amniotic fluid helps to promote the body’s own healing process to assist in the reconstruction and regeneration of injured tissue within the epidermal layer.

In January 2017, Ryan Salvino and Jonathan Benstent founded Russell Health, Inc., on the premise of helping others achieve pain relief and healing with regenerative medicine derived from acellular placental tissue and fluid products. 

Salvino and Benstent were childhood friends who grew up in the suburbs of Chicago. Both attended Butler University in Indianapolis, where they bonded over a mutual passion for en-trepreneurship. By the early 2010s, both had moved to the Chicagoland area — Salvino working on an MBA, and Benstent studying advanced software engineering. 

Inspired by the positive effects that amniotic fluid and placental tissue has on the body to promote healing and decrease inflammation, Salvino and Benstent founded Russell Health, Inc., with the goal of providing medical professionals with the tools to treat patients with Stem Cell Recruitment™. This led to the creation of the Stem Cell Recruitment Facial™ treatment utilizing DermaFlo™. Stem Cell Recruitment (SCR) Facial™ combines DermaFlo™ and the patent-pending SCR Facial™ Procedure Guide that utilizes a minimally invasive technique. DermaFlo™ is an acellular, chorion-free, pure amniotic fluid product that manages the cellular activity within the dermal layer. Patients have reported improved laxity and coloration of skin and reduction of fine lines and definition of jawline, as well as diminished appearance of post acne scarring.

 Stem Cell Recruitment™(SCR), Stem Cell Recruitment Therapy™(SCRT), SCR Facial™, DermaFlo™, OrthoFactor™ and Vivaderm™ are trademarks of Russell Health, Inc. The treatments described on this marketing are not considered to be standard of care for any condition or disease. SCR, SCRT, SCR Facial and Vivaderm™ attempt to utilize acellular, minimally manipulated tissue allografts and are comprised of tissue allograft components intended for homologous use to supplement tissue. SCRT products are classified by the Food and Drug Administration (FDA) as Human Cell, Tissue and Cellular and Tissue-Based Products (HCT/P) that are regulated solely under section 361 of the Public Health Service (PHS) Act. FDA recognizes that human tissue was designed, or evolved, to perform certain functions in the human body with exquisite safety and effectiveness. See more information about safety and compliance at www.russellhealth.com.

The framework of the products behind Russell Health’s mission to provide physicians with products and tissues to help the body heal itself.