Dermala, a consumer dermatology company who develops novel, personalized, microbiome-based treatments for multiple skin conditions, has announced the issuance of the U.S. Patent No. 11,103,443 - compositions and methods for preventing, slowing, and reversing skin aging.

The patent covers using the human microbiome to slow down the skin aging process, according to the press release. Typical signs of skin aging are wrinkles, loss of skin elasticity, skin sagging, blemishes, and hyperpigmentation. As a person ages, the microbiomes of the skin and gut change as well. The goal of Dermala’s patented technology is to balance the microbiome and restore younger skin and gut microbiomes in older adults. 

Dermala transplants “younger” skin and gut microbiomes or their biosynthetic equivalents— prebiotics, probiotics, and postbiotics—to older skin. The company says this results in a rebalanced microbiome, the reduction of fine lines and wrinkles, improved skin hydration, increased ceramide and collagen production, reduced inflammation, improved skin barrier function and elasticity, and a younger complexion.

"Skin aging is associated with changes in skin and gut microbial communities," says Lada Rasochova, PhD, MBA, founder and CEO of Dermala and patent inventor, San Diego, California. "Differences between younger and older microbiomes can be striking. Optimizing the microbiome composition by transplanting biologically younger microbiome components onto an aging skin to slow down aging is a novel concept that is poised to revolutionize the skincare industry."

This patent expands Dermala's intellectual property portfolio, which includes using the skin and gut microbiomes and data analytics to treat skin diseases and conditions such as acne, eczema, and skin aging.

1. Dermala, a consumer dermatology company, announces issuance of a new U.S. Patent covering the use of human microbiome to prevent, slow, and reverse skin aging. Cision PR Newswire. Press release. Published September 13, 2021. Accessed September 16, 2021. https://www.prnewswire.com/news-releases/dermala-a-consumer-dermatology-company-announces-issuance-of-a-new-us-patent-covering-the-use-of-human-microbiome-to-prevent-slow-and-reverse-skin-aging-301374929.html

Articles

Dermala announces a patent for compositions and methods for preventing, slowing, and reversing skin aging.

Dermala is Granted Patent for Microbiome Anti-Aging

In this week’s video, Dustin Portela, DO, a board-certified dermatologist and dermatologic surgeon at Treasure Valley Dermatology in Boise, Idaho, explains pimple patches and hydrocolloid patches, how they work, and which one works best.

Portela dives into how to get rid of a pimple once it has come to the surface of the skin. The object of these patches are to help create an environment to help the skin heal faster. While a pimple patch can come medicated, hydrocolloid patches do not, thus creating a difference in how they work. 

Watch the video below for more on pimple and hydrocolloid patches.

Opinions expressed are that of Portela and do not express the views or opinions of 

This week’s Pointers With Dr Portela, Dustin Portela, DO, explains pimple patches and hydrocolloid patches, diving into how to treat acne when it surfaces. 

Pointers With Dr Portela: Battle of the Pimple Patches

A prospective, IRB-approved study published in the 

 journal investigated the safety and efficacy of the 730nm picosecond-domain laser for the clearance of lentigines and how the short picosecond pulses affect the tissue histologically.1

There were 20 patients with Fitzpatrick skin types II-IV enrolled in the trial and they received 4 treatments from the laser. Photos were taken before and after treatment then assessed by blinded reviewers at 4- and 12-week follow-up visits by a 5-point clearance scale, and patient satisfaction was measured on a 5-point scale. An investigator Global Improvement Score (IGIS) was evaluated with an 11-point clearance scale at the 4- and 12-week follow-up, also. The patients pain level was measured from 0 (no pain) to 10 (extreme pain) and the histology of 730 and 532 nm picosecond pulses was compared to 755 and 532 nm nanosecond pulses.

Out of the 20 patients enrolled, 16 completed all the study visits, with a mean age of 63 years and 75% were female and 25% were male. These 16 patients had 118 treatment areas, each of which included 1 to 20 lesions and 30 body regions were studied (arms (6), hands (16), scalp (1), forehead (2), face (3), and back (2)). The spot sizes ranged from 2 to 5 mm diameters were used with fluences ranging from 0.8 to 4.0 J/cm2.

The mean pain score was 3.6 out of 10 for each of the 4 treatments that the patients received. When the photos of the treated skin were assessed by the blind investigators, only 1 photo at 4 weeks were misidentified as a post treatment photo, leading to 99% of randomly paired 4-week posttreatment images and 100% of 12-week posttreatment images were correctly identified.

The mean scores of IGIS were 6.7 at the 4 week follow up and 7.0 at the 12 week follow up visits with 76% and 73% of patients respectively were satisfied to highly satisfied. The mean clearance score for the 118 treatment areas was 3 of 4 at follow up visits. At the 12 week follow up, 36% of the 118 treatment areas has a clearance score of 4 and 38% had a score of 3. The adverse event (AEs) experienced were considered typical by study authors and included erythema, edema, dryness, crusting, and itching.

Histology showed diffuse, focal epidermal vacuolization ~5–10 µm in diameter and mild extravasation of erythrocytes with 730 nm picosecond pulses, according to the study authors, while diffuse epidermal vacuolization was observed in the joining of vacuoles (~20–100 µm), junctional clefting and mild extravasation of erythrocytes with 755 nm nanosecond pulses.

“Picosecond pulses of the wavelength of 532 nm produced diffuse, focal epidermal vacuolization and larger dermal vacuoles to depths of 500 µm, while 532 nm nanosecond pulses produced diffuse epidermal vacuolization with coalescence of vacuoles and marked dermal hemorrhage,” wrote study authors.

The 730 nm picosecond-domain laser for the clearance of lentigines has shown potential for treatment according to the study, which good clearance, safety, and patient satisfaction in patients with skin type II-III. The histology found the laser produces excellent selectively for pigment with minimal disruption of the dermal-epidermal junction and may reduce healing times or AEs, according to the study authors.

Further investigation needs done on darker skin tones, according to the study authors.

1. Kauvar ANB, Sun R, Bhawan J, et al. Treatment of facial and non-facial lentigines with a 730 nm picosecond titanium: Sapphire laser is safe and effective. Lasers in Surgery and Medicine. n/a(n/a). doi:10.1002/lsm.23450

A recent study delved into how well the 730 nm picosecond-domain laser could treat facial and non-facial lentigines in patients.

Study: 730 nm Picosecond Laser for Treatment of Lentigines

SkinCeuticals launches a brand-new scar gel aimed at improving the texture and tone of existing scars and preventing new ones from forming. This high-silicone scar gel consists of 95% silicones, 0.5% allantoin, 2% fatty acids, and 1% ultralight silica. Alcohol-, dye-, and fragrance-free, SkinCeuticals’ Advanced Scar Control improves the overall appearance of recent scars by 29% in 12 weeks as seen in clinical trials, with study subjects seeing an improvement in new/recent scar redness, texture, and discoloration.

Re:generative™ Super Power C Serum | I-N Beauty

This vitamin C serum is driven by I-N Beauty’s Intelli-Cell™ plant stem cell science to help reduce fine lines and wrinkles, dark spots, uneven skin tone, and redness. According to the company, Intelli-Cell™ is 1000x more potent and sustainable than conventional ingredients. Stem cells from rare plants such as edelweiss, coneflower, and pennywort are extracted to harness their anti-aging and antioxidant effects. Although vitamin C has a bad rap for having a short shelf life and being unstable, this vitamin C serum, however, is stabilized using I-N Beauty’s technology to remain resistant to discoloration during production, storage, and use. 

Elixir Firming Serum from Antedotum aids in collagen restoration, resulting is hydrated, firm skin free of any signs of hyperpigmentation and sagging. Formulated with a full-spectrum CBD, this firming serum contains 1 of the highest concentrations (500 mg) of cannabinoids, including CBD and CBG. These plant compounds are rich in anti-inflammatory and anti-oxidative properties that aid in soothing skin irritation, reducing redness, oil control, and protecting against cell degradation due to their neuro-regenerative properties, according to Antedotum.

Zit Stopper | The A Method by Tina Alster MD

’ editorial advisory board member, comes Zit Stopper, a twice-daily topical acne treatment formulated with key ingredients adapalene 1%, trichloroacetic acid, hydrocortisone, glycerin, and hyaluronic acid. A previously prescription-only medication for acne, adapalene has shown in numerous clinical studies to prevent and reduce acne break outs. 

Anti-Aging Facial Serum Concentrate | KERACELL MD

KERACELL MD’s Anti-Aging Facial Serum Concentrate features High Potency MHCsc (Multiple Human Cell Stem Cell) Technology, which is formulated with W3 Peptide (Hexapeptide-33), a 3rd generation skin care peptide that targets G-protein-coupled receptors (GPCR). This technology helps activate cell vitality, brightens, tones, and combats wrinkles. The serum is equipped with potent bio-active signaling peptides to target damaged sites to assist in restoration and repair. Also, Gatuline Renew works to smooth and hydrate the skin to improve overall skin texture and appearance.

Lubriderm Advanced Therapy Moisturizing Cream Fragrance-Free | Lubriderm

A new moisturizing cream has hit the market with the introduction of Lubriderm’s Advanced Therapy Moisturizing Cream. This cream aims to relieve extra-dry skin through vitamin E, pro-vitamin B5, and omega 3. Lubriderm’s new fragrance- and paraben-free cream is fast-absorbing and has shown to moisturize for 24 hours, leaving the skin intensely hydrated without that dreaded greasy feeling.

Click here to find out what products are trending for the month of September.

What’s Trending in Skin Care? September 2021 

 details the importance of wearing sunscreen as a person of color, 

 talks concierge IV services boosting beauty, and 

 highlights pro-retinol and the true cost of hair loss treatments.

Yes, People With Dark Skin Tones Need to Use Sunscreen—Even Indoors

Are You Moisturizing All Wrong? Don't Make These 8 Common Mistakes

Pro-Retinol Packs a Gentle Power Duo to Smooth Skin

Everything to Know About At-Home IV Drips 

This week, consumer magazines highlight the true cost of hair loss treatments, pro-retinol, and more.  

The True Cost of Hair Loss Treatments 

This week in aesthetics, Will Kirby, DO, FAOCD, interviews Azadeh Shirazi, MD, in this month’s “Meet the Aesthetic Expert” column, Jill S. Waibel, MD, discusses new frontiers in laser, light, and optical devices, Monica Bonakdar, MD, shares her thoughts on combination therapies, InMode announces its EmpowerRF Women's Wellness platform, and Dustin Portela, DO, explains how to repair the skin moisture barrier in his new “Pointers with Dr Portela” weekly video series.

Meet the Aesthetic Expert with Dr Will Kirby: Azadeh Shirazi, MD

In this month’s “Meet the Aesthetic Expert” column, Will Kirby, DO, FAOCD, talks with Azadeh Shirazi, MD, board-certified dermatologist, founder of La Jolla Dermatology & Laser Surgery Center, and AziMD Skincare, about opening her own practice, aesthetic conferences, and her podcast, More than a Pretty Face.

New Frontiers in Laser, Light, Optical Devices

Innovations include underserved populations, acne, and advanced applications.

Combination Therapies with Monica Bonakdar, MD

We interview Monica Bonakdar, MD about her thoughts on combination therapies, how COVID-19 has affected her practice, and more.

InMode Launches EmpowerRF Women’s Wellness Platform

InMode announces the launched of the EmpowerRF Women's Wellness platform to help deliver wellness therapies.

Pointers with Dr Portela: How to Fix a Broken Skin Moisture Barrier

In this week's Pointers with Dr Portela, the 208SkinDoc explains how to repair the skin moisture barrier.

This week in aesthetics, we highlight this month’s “Meet the Aesthetic Expert” column, launch our new “Pointers with Dr Portela” weekly video, and more.  